Migraine, tension-type headache and cluster headache are associated with impaired energy metabolism in the brain. This fact has been known for several decades. But how do we apply this knowledge to the main questions regarding primary headaches: What causes headache and how can we heal it? In this article I review the existing evidence, and based on my personal experience of using coMra-Therapy to treat high-altitude severe headaches I propose a new view of the biology of headaches.

In “A new approach to healing headaches: 1 Bioenergetic basis” I presented experimental evidence of acute cellular energy deficit involved in headaches. Simply put, whenever the brain is critically low on energy it sends a warning in the form of a pain sensation: “Whatever you are doing, it is damaging!”

But what causes this bioenergetic deficit? Is there a common cause between tension-type headaches and chronic migraine? In this article I will explore deeper insights into the origin of pain in the subjective experience of headaches. Then I will try to connect that subjective experience to the bioenergetic nature, the biology of headaches. This will allow us to search for ways of treating primary headaches.

In parts 1 and 2 of this article I put together experimental observations and subjective experiences to lay a foundation for a new and holistic view of primary headaches. In this third and final part of the article I summarise this view and share my understanding of how coMra-Therapy can play a most decisive role in a holistic approach towards healing and curing even the most debilitating headaches.

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